Study
T-cell based immunotherapies show remarkable potential for treating cancer, autoimmunity, and infectious disease. Although studying T-cell biology and developing potential therapeutics relies on gene delivery, effective, scalable T-cell modification remains a technical challenge.
Traditional gene delivery methods like viral vectors and electroporation come with risks for mutagenesis, immunogenicity, cell damage, or poor efficiency. Non-viral mRNA transfection offers a safe, less expensive, and more efficient alternative for T-cells and other difficult-to-transfect cell types.
Download this study from Sartorius for a detailed example of how to optimize mRNA transfection in human T-cells and receive a complimentary mRNA transfection reagent sample.
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