Accelerate Monoclonal Antibody Discovery With Smarter Single B Cell Screening
Combining the PentaMice® platform with single B cell screening using the Berkeley Lights Beacon® Optofluidic system offers a powerful solution for accelerating the development of monoclonal antibody therapeutics. The Beacon® system leverages cutting-edge technology — including light manipulation, nanofluidics, and advanced AI algorithms — to isolate and maneuver individual B cells into NanoPen™ chambers for high-throughput screening. This integrated approach significantly enhances speed to market by streamlining early discovery and selection of candidate antibodies.
Our white paper explores key insights into this process, including First-to-Human antibody development strategies, the use of the PentaMice® platform for targeted immunization, and the precision of single B cell screening. Additional topics include sequence identification, custom bioinformatics solutions, and gene-to-protein expression strategies. A featured case study highlights the successful discovery of diverse monoclonal antibodies targeting SARS-CoV-2 Delta and Omicron spike proteins.
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