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In today’s competitive pharmaceutical landscape, drug developers are continually seeking innovative strategies to enhance bioavailability, improve patient compliance and expedite therapeutic outcomes. Pregastric absorption has emerged as a critical pathway to achieve these goals by enabling drugs to bypass gastrointestinal degradation and first-pass metabolism. This article explores the latest advancements in buccal and sublingual delivery systems, the impact of permeation enhancers and the role of PBPK modeling in predictive formulation design. The article also discusses how rapid-dissolving orally disintegrating tablets (ODTs) are influencing the development of patient-centric formulations, all with the goal of improving therapeutic efficacy and patient experience.
Learn more about:
- Formulation strategies that improve pregastric drug absorption, including permeation enhancers and Zydis® ODT
- Using PBPK modeling to simulate and predict oral cavity drug absorption, helping accelerate formulation timelines
- Designing patient-friendly ODTs that enhance pregastric delivery, improve taste, and increase ease of administration for better compliance
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