Custom TFF system design and flexible manufacturing solutions
- A major biopharmaceutical manufacturer faced inefficiencies in preparing and transferring media for perfused stirred-tank and rocker bioreactors.
- To streamline operations, the facility implemented Avantor’s custom inline conditioning system, enabling real-time dilution and mixing of concentrated media and buffer components directly before delivery to bioreactors.
- The automated skid integrated hybrid single-use and stainless steel components, surge tanks, static mixers, leak detection and CIP capabilities while reducing high-pressure WFI for single-use materials.
- Seamless integration with the site’s automation platform ensured accurate dosing, continuous monitoring and automatic batch record logging, minimizing human error and enhancing regulatory compliance.
- The solution significantly reduced preparation times, labor requirements and operational risk while improving data integrity and scalability, transforming media handling into an efficient, automated, GMP-compliant process.
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