How CleanCap® co-transcriptional capping strategy can be advantageous
TriLink’s CleanCap® AU analog is designed for the co-transcriptional capping of RNA to produce self-replicating RNAs which are based on the genomes of positive sense (+) strand RNA viruses such as Venezuelan equine encephalitis virus (VEEV), Semliki forest virus (SFV), and Sindbis virus (SIN). The (+) strand genomes of these viruses start with a 5′-AU. Cap-1 RNAs produced by CleanCap AU are more suitable for eukaryotic usage than Cap-0 RNAs produced by legacy co-transcriptional capping methods such as anti-reverse cap analog (ARCA). Compared to enzymatic capping, CleanCap technology offers more streamlined and efficient manufacturing of self-amplifying RNAs. In addition, CleanCap AU analog can be used in conjunction with TriLink’s catalog of modified and unmodified NTPs.
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